Drug Delivery and Biophysics of Biopharmaceuticals

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  1. 2020
  2. Published

    Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

    Kristensen, Mie, Diedrichsen, Ragna Guldsmed, Vetri, V., Foderà, Vito & Nielsen, Hanne Mørck, 2020, In: Pharmaceutics. 12, 10, 18 p., 993.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Membrane interactions in drug delivery: Model cell membranes and orthogonal techniques

    Bunea, A., Rønholt, Stine, Taboryski, R. & Nielsen, Hanne Mørck, 2020, In: Advances in Colloid and Interface Science. 281, 15 p., 102177.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration

    Agnoletti, M., Rodríguez-Rodríguez, C., Klodzinska, S. N., Esposito, T., Saatchi, K., Nielsen, Hanne Mørck & Häfeli, U. O., 2020, In: ACS Nano. 14, p. 6693-6706

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Quality by Design thinking in the development of long-acting injectable PLGA/PLA-based microspheres for peptide and protein drug delivery

    Zhang, C., Yang, L., Wan, F., Bera, H., Cun, D., Rantanen, Jukka & Yang, Mingshi, 2020, In: International Journal of Pharmaceutics. 585, 19 p., 119441.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Quantitative Comparison of Three Widely-Used Pulmonary Administration Methods In Vivo with Radiolabeled Inhalable Nanoparticles

    Wu, L., Rodríguez-Rodríguez, C., Cun, D., Yang, Mingshi, Saatchi, K. & Häfeli, U. O., 2020, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 152, p. 108-115

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Refinement and validation of infrared thermal imaging (IRT): a non-invasive technique to measure disease activity in a mouse model of rheumatoid arthritis

    Nosrati, Z., Bergamo, M., Rodriguez-Rodriguez, C., Saatchi, K. & Hafeli, U. O., 2020, In: Arthritis Research & Therapy. 22, 1, 16 p., 281.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Shuffled lipidation pattern and degree of lipidation determines the membrane interaction behavior of a linear cationic membrane-active peptide

    Hedegaard, S. F., Bruhn, D. S., Khandelia, H., Cardenas, M. & Nielsen, Hanne Mørck, 2020, In: Journal of Colloid and Interface Science. 578, p. 584-597 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms

    Huang, Z., Zhou, T., Yuan, Y., Klodziska, S. N., Zheng, T., Sternberg, C., Nielsen, Hanne Mørck, Sun, Y. & Wan, F., 2020, In: Journal of Colloid and Interface Science. 577, p. 66-74 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Thiol-Ene Based Polymers as Versatile Materials for Microfluidic Devices for Life Sciences Applications

    Sticker, Drago, Geczy, R., Häfeli, U. O. & Kutter, Jörg P., 2020, In: A C S Applied Materials and Interfaces. 12, 9, p. 10080-10095

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Tracking Internal and Global Diffusive Dynamics During Protein Aggregation by High-Resolution Neutron Spectroscopy

    Pounot, K., Chaaban, Hussein Forsberg, Foderà, Vito, Schirò, G., Weik, M. & Seydel, T., 2020, In: The Journal of Physical Chemistry Letters. 11, 15, p. 6299-6304 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  12. Published

    Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

    Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, S., Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Hafeli, U. O., 2020, In: Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

    Stie, Mai Bay, Corezzi, M., Juncos Bombin, A. D., Ajalloueian, F., Attrill, E., Pagliara, S., Jacobsen, Jette, Chronakis, I. S., Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: ACS Applied Nano Materials. 3, 2, p. 1910–1921

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring

    Guo, X., Liu, Y., Bera, H., Zhang, H., Chen, Y., Cun, D., Foderà, Vito & Yang, Mingshi, 2020, In: A C S Applied Materials and Interfaces. 12, 41, p. 45702-45713 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2019
  17. Published

    Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures

    Streck, S., Neumann, H., Nielsen, Hanne Mørck, Rades, Thomas & McDowell, A., Dec 2019, In: International Journal of Pharmaceutics: X. 1, 9 p., 100030.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    MEDICINES AUTHORITY REGULATOR AND INDUSTRY PERCEPTIONS OF BIOSIMILAR INTERCHANGEABILITY

    Druedahl, Louise C., De Bruin, M. L., Hoogland, H., Minssen, Timo, van de Weert, Marco, Kälvemark Sporrong, Sofia & Almarsdóttir, Anna Birna, Dec 2019, p. E45-E46.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  19. Published

    The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering

    Streck, S., Clulow, A. J., Nielsen, Hanne Mørck, Rades, Thomas, Boyd, B. J. & McDowell, A., 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 438-448 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles

    Kłodzińska, S. N., Wan, F., Jumaa, H., Sternberg, C., Rades, Thomas & Nielsen, Hanne Mørck, 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 595-606 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

    Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, Mai Bay, Nielsen, Hanne Mørck, Janfelt, Christian, Hatton, P. V. & Jacobsen, Jette, Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Preanalytical Stability of Piperacillin, Tazobactam, Meropenem, and Ceftazidime in Plasma and Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry

    Mortensen, Janni Støvring, Jensen, B. P., Zhang, M. & Doogue, M., Aug 2019, In: Therapeutic Drug Monitoring. 41, 4, p. 538-543

    Research output: Contribution to journal › Letter › Research › peer-review

  23. Published

    Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics

    Baker, K. R., Jana, B., Hansen, A. M., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

    Stie, Mai Bay, Jones, M., Sørensen, H. O., Jacobsen, Jette, Chronakis, I. S. & Nielsen, Hanne Mørck, 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The dangers of citing papers you did not read or understand

    van de Weert, Marco & Stella, L., 15 Jun 2019, In: Journal of Molecular Structure: THEOCHEM. 1186, p. 102-103 2 p.

    Research output: Contribution to journal › Journal article › Communication

  26. Published

    Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement

    Malekkhaiat Häffner, S., Nyström, L., Browning, K. L., Nielsen, Hanne Mørck, Strömstedt, A. A., van der Plas, Mariena J.A., Schmidtchen, A. & Malmsten, Martin, 1 May 2019, In: A C S Applied Materials and Interfaces. 11, 17, p. 15389-15400 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Direct observation of alpha-lactalbumin, adsorption and incorporation into lipid membrane and formation of lipid/protein hybrid structures

    Rao, E., Foderà, Vito, Leone, M. & Vetri, V., May 2019, In: B B A - General Subjects. 1863, 5, p. 784-794

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model

    Wang, C., Iashchishyn, I. A., Kara, J., Foderà, Vito, Vetri, V., Sancataldo, G., Marklund, N. & Morozova-Roche, L. A., 23 Apr 2019, In: Neuroscience Letters. 699, p. 199-205

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

    Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Optical catapulting of microspheres in mucus models-toward overcoming the mucus biobarrier

    Bunea, A., Chouliara, M., Rønholt, Stine, Banas, A. R., Engay, E. L. & Gluckstad, J., Mar 2019, In: Journal of Biomedical Optics. 24, 3, 10 p., 035001.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells

    Stie, Mai Bay, Thoke, H. S., Issinger, O. G., Hochscherf, J., Guerra, B. & Olsen, L. F., 1 Feb 2019, In: Colloids and Surfaces B: Biointerfaces. 174, p. 216-223 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Microfluidic approaches for the production of monodisperse, superparamagnetic microspheres in the low micrometer size range

    Géczy, R., Agnoletti, M., Hansen, M. F., Kutter, Jörg P., Saatchi, K. & Häfeli, U. O., 1 Feb 2019, In: Journal of Magnetism and Magnetic Materials. 471, p. 286-293

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals

    Rønholt, Stine, Fliervoet, L. A. L., Fano, M., Schmitt, M., Antopolski, M., Urtti, A. & Nielsen, Hanne Mørck, 1 Jan 2019, In: Drug Delivery. 26, 1, p. 532-541

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR

    Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

    Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Chloroform compatible, thiol-ene based replica molded micro chemical devices as an alternative to glass microfluidic chips

    Geczy, R., Sticker, Drago, Bovet, N., Hafeli, U. O. & Kutter, Jörg P., 2019, In: Lab on a Chip. 5, p. 798-806 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors

    Guo, X., Zhao, Z., Chen, D., Qiao, M., Wan, F., Cun, D., Sun, Y. & Yang, Mingshi, 2019, In: Asian Journal of Pharmaceutical Sciences. 14, 1, p. 78-85 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Danish Physicians’ Views on the Appropriateness of the Involvement of Patients with Type 2 Diabetes in Regulatory Decision Making: A Qualitative Study

    Sachs, M. L., Colding-Jørgensen, M., Helboe, P., Kälvemark Sporrong, Sofia, Frøkjær, Sven, Jelic, K. & Kaae, Susanne, 2019, In: Pharmaceutical Medicine. 33, 2, p. 99-107

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species

    Skamris, T., Marasini, C., Madsen, Kenneth Lindegaard, Foderà, Vito & Vestergaard, Bente, 2019, In: Scientific Reports. 9, p. 1-11 11 p., 1733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Effect of thermal and shear stresses in the spray drying process on the stability of siRNA dry powders

    Wu, J., Wu, L., Wan, F., Rantanen, Jukka, Cun, D. & Yang, Mingshi, 2019, In: International Journal of Pharmaceutics. 566, p. 32-39 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Flexibility defines structure in crystals of amphiphilic DNA nanostars

    Brady, R. A., Kaufhold, W. T., Brooks, N. J., Foderà, Vito & Di Michele, L., 2019, In: Journal of Physics: Condensed Matter. 31, 7, 11 p., 0704003.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5

    Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, Thomas, Hancock, R. E. W. & Nielsen, Hanne Mørck, 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats

    Vargas Christensen, I., Loftager, M., Rode, F., Nielsen, Hanne Mørck, Kreilgaard, M. & Larsen, M. S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 6, p. 964-974 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Impact of drug loading in mesoporous silica-amorphous formulations on the physical stability of drugs with high recrystallization tendency

    Antonino, R. S. C. M. Q., Ruggiero, M., Song, Z., Nascimento, T. L., Lima, E. M., Bohr, A., Knopp, Matthias Manne & Löbmann, Korbinian, 2019, In: International Journal of Pharmaceutics: X. 1, 7 p., 100026.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model

    Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Mapping the Diversity of Protein Aggregates

    Foderà, Vito, 2019, p. S87-S87.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  47. Published

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

    Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Medicines authority regulators and industry perspectives on the European regulation of biosimilars

    Druedahl, Louise C., De Bruin, M. L. (., van de Weert, Marco, Minssen, Timo, Hoogland, H. & Almarsdóttir, Anna Birna, 2019.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  49. Published

    Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

    Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Non-aqueous topical compositions comprising a halogenated salicylanilide

    Sommer, M., Li, P., Frandsen, C. H., Nielsen, Hanne Mørck, Priemel, P. A. & Rades, Thomas, 2019, Patent No. US20190151231A1

    Research output: Patent

  51. Published

    Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

    Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2018
  53. Published

    Amphiphilic-DNA Platform for the Design of Crystalline Frameworks with Programmable Structure and Functionality

    Brady, R. A., Brooks, N. J., Foderà, Vito, Cicuta, P. & Di Michele, L., 14 Nov 2018, In: Journal of the American Chemical Society. 140, 45, p. 15384-15392

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles

    Wu, C., van de Weert, Marco, Baldursdottir, S. G., Yang, Mingshi & Mu, Huiling, 25 Oct 2018, In: International Journal of Pharmaceutics. 550, 1-2, p. 439-446

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation

    von Halling Laier, C., Gibson, B., van de Weert, Marco, Boyd, B. J., Rades, Thomas, Boisen, A., Hook, S. & Nielsen, L. H., 25 Oct 2018, In: International Journal of Pharmaceutics. 550, 1-2, p. 35-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages

    Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, Mingshi & Nielsen, Hanne Mørck, Aug 2018, In: Journal of Pharmacy and Pharmacology. 70, 8, p. 1009-1021

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic

    Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

    de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium

    Birch, D., Diedrichsen, Ragna Guldsmed, Christophersen, P. C., Mu, Huiling & Nielsen, Hanne Mørck, Jun 2018, In: European Journal of Pharmaceutical Sciences. 118, p. 144-153

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

    Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites

    Vetri, V., Piccirilli, F., Krausser, J., Buscarino, G., Łapińska, U., Vestergaard, Bente, Zaccone, A. & Foderà, Vito, 29 Mar 2018, In: The Journal of Physical Chemistry B. 122, 12, p. 3101-3112

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

    Høgstedt, U. B., Østergaard, Jesper, Weiss, T., Sjögren, H. & van de Weert, Marco, Mar 2018, In: Journal of Pharmaceutical Sciences. 107, 3, p. 838-847 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

    Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

    Liu, X., Nielsen, L. H., Klodzinska, S. N., Nielsen, Hanne Mørck, Qu, H., Christensen, L. P., Rantanen, Jukka & Yang, Mingshi, Feb 2018, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 123, p. 42-49

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Combining diagnostic methods for antimicrobial susceptibility testing – A comparative approach

    Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, Jan 2018, In: Journal of Microbiological Methods. 144, p. 177-185

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

    García-Díaz, M., Birch, D., Wan, F. & Nielsen, Hanne Mørck, Jan 2018, In: Advanced Drug Delivery Reviews. 124, p. 107-124

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Transport mechanism of lipid covered saquinavir pure drug nanoparticles in intestinal epithelium

    Xia, D., He, Y., Li, Q., Hu, C., Huang, W., Zhang, Y., Wan, F., Wang, C. & Gan, Y., Jan 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 269, p. 159-170

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH

    Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

    Nielsen, Hanne Mørck, 2018, In: European Journal of Pharmaceutics and Biopharmaceutics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin

    Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  71. Published

    Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

    Thakur, A., Rodríguez-Rodríguez, C., Saatchi, K., Rose, F., Esposito, T., Nosrati, Z., Andersen, P., Christensen, D., Häfeli, U. O. & Foged, Camilla, 2018, In: Frontiers in Immunology. 9, 21 p., 2825.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction

    Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

    Wan, F., Larsen, F. H., Nunes Bordallo, Heloisa, Foged, Camilla, Rantanen, Jukka & Yang, Mingshi, 2018, In: A C S Applied Materials and Interfaces. 10, 43, p. 36686-36692

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

    Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, Foged, Camilla, 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  75. Published

    Temperature-Induced Self-Assembly of the Group B Streptococcus (GBS) Fusion Antigen GBS-NN

    Rose, F., Roovers, S., Fano, M., Rønholt, Stine, Kirkensgaard, Jacob Judas Kain, Hejnaes, K., Fischer, P. & Foged, Camilla, 2018, In: Molecular Pharmaceutics. 15, p. 2584-2593 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

    Nielsen, Hanne Mørck, 2018, In: Advanced Drug Delivery Reviews.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. 2017
  78. Published

    Animal models for evaluation of oral delivery of biopharmaceuticals

    Rønholt, Stine, Nielsen, L. H. & Nielsen, Hanne Mørck, Dec 2017, In: Journal of Controlled Release. 268, p. 57-71 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  79. Published

    Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

    Agnoletti, M., Bohr, A., Thanki, K., Wan, F., Zeng, X., Bøtker, Johan Peter, Yang, Mingshi & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 9-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Interaction with prefibrillar species and amyloid-like fibrils changes the stiffness of lipid bilayers

    Borro, B. C., Parolini, L., Cicuta, P., Foderà, Vito & Di Michele, L., 25 Oct 2017, In: Physical chemistry chemical physics : PCCP. 19, 41, p. 27930-27934 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Protein-membrane interaction: insights from advanced microscopy

    Rao, E., Vetri, V., Foderà, Vito & Leone, M., Jul 2017, p. S351-S351.

    Research output: Contribution to conference › Conference abstract for conference › Research

  82. Published

    Adjuvants based on synthetic mycobacterial cord factor analogues: Biophysical properties of neat glycolipids and nano-self-assemblies with DDA

    Kallerup, R. S., Franzyk, Henrik, Schiøth, M. L., Justesen, S., Martin-Bertelsen, Birte, Rose, F., Madsen, C. M., Christensen, D., Korsholm, K. S., Yaghmur, Anan & Foged, Camilla, 12 May 2017, In: Molecular Pharmaceutics. 14, 7, p. 2294-2306 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Assessment of mucoadhesion using small deformation rheology revisited

    Rønholt, Stine, Vissing, K. J. & Nielsen, Hanne Mørck, Apr 2017, In: Nordic Rheology Society Annual Transactions. 25, p. 63 7 p.

    Research output: Contribution to journal › Conference article › Research › peer-review

  84. Published

    Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability

    Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Sucrose modulates insulin amyloid-like fibril formation: effect on the aggregation mechanism and fibril morphology

    Marasini, C., Foderà, Vito & Vestergaard, Bente, 2017, In: RSC Advances. 7, p. 10487-10493

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy

    Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

    Research output: Contribution to conference › Poster › Research

  87. 2016
  88. Published

    Conserved molecular superlattices in a series of homologous synthetic mycobacterial cell-wall lipids forming interdigitated bilayers

    Martin-Bertelsen, Birte, Yaghmur, Anan, Franzyk, Henrik, Justesen, S., Kirkensgaard, Jacob Judas Kain & Foged, Camilla, 7 Nov 2016, In: Langmuir. 32, 48, p. 12693–12701 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Use of fluorescent probes for ROS to tease apart Type I and Type II photochemical pathways in photodynamic therapy

    Garcia-Diaz, M., Huang, Y. & Hamblin, M. R., 15 Oct 2016, In: Methods. 109, p. 158-166 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers

    Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2743-51 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Mapping surface charge density of lipid bilayers by quantitative surface conductivity microscopy

    Klausen, L. H., Fuhs, T. & Dong, M., 26 Aug 2016, In: Nature Communications. 7, p. 1-10 10 p., 12447.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile

    Schmidt, S. T., Khadke, S., Korsholm, K. S., Perrie, Y., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 26 Aug 2016, In: Journal of controlled release : official journal of the Controlled Release Society. 239, p. 107-117 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages invitro and adjuvant activity invivo

    Huber, A., Kallerup, R. S., Korsholm, K. S., Franzyk, Henrik, Lepenies, B., Christensen, D., Foged, Camilla & Lang, R., Aug 2016, In: Innate Immunity. 22, 6, p. 405-418 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions

    Høgstedt, U. B., Schwach, G., van de Weert, Marco & Østergaard, Jesper, 25 Jul 2016, In: European Journal of Pharmaceutical Sciences. 93, p. 21-28 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation

    Lobbens, E. S., Breydo, L., Pedersen, T. S., Vestergaard, Bente, Jäger, A. K., Jørgensen, Lene, Uversky, V. & van de Weert, Marco, 21 Jun 2016, In: B B A - Proteins and Proteomics. 1864, 9, p. 1160-1169 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

    Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

    Schmidt, S. T., Foged, Camilla, Korsholm, K. S., Rades, Thomas & Christensen, D., 10 Mar 2016, In: Pharmaceutics. 8, 1, 22 p., 7.

    Research output: Contribution to journal › Review › Research › peer-review

  98. Published

    Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

    Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 7 Mar 2016, In: Molecular Pharmaceutics. 13, 3, p. 748-55 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products – A Study Using Aloin and Insulin

    Lobbens, E. S., Foderà, Vito, Nyberg, N., Andersen, K., Jäger, A. K., Jørgensen, Lene & van de Weert, Marco, 16 Feb 2016, In: PloS one. 11, 2, p. 1-16 16 p., e0149148.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying

    Wan, F. & Yang, Mingshi, 10 Feb 2016, In: International Journal of Pharmaceutics. 498, 1-2, p. 82-95 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  101. Published

    Cell-Penetrating Peptides as Carriers for Oral Delivery of Biopharmaceuticals

    Kristensen, Mie & Nielsen, Hanne Mørck, Feb 2016, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 2, p. 99-106 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. Published

    Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

    Kristensen, Mie, Birch, D. & Nielsen, Hanne Mørck, 30 Jan 2016, In: International Journal of Molecular Sciences . 17, 2, p. 1-17 17 p., 185.

    Research output: Contribution to journal › Review › Research › peer-review

  103. Published

    Back to the oligomeric state pH-induced dissolution of concanavalin A amyloid-like fibrils into non-native oligomers

    Santangelo, M. G., Foderà, Vito, Militello, V. & Vetri, V., 2016, In: RSC Advances. 6, 79, p. 75082-75091 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals

    Kristensen, Mie & Nielsen, Hanne Mørck, 2016, In: Tissue Barriers. 4, 2, 15 p., e1178369.

    Research output: Contribution to journal › Review › Research › peer-review

  105. Published

    Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization

    Fonte, P., Andrade, F., Azevedo, C., Pinto, J., Seabra, V., van de Weert, Marco, Reis, S. & Sarmento, B., 2016, In: Pharmaceutical Research. 33, 11, p. 2777–2793

    Research output: Contribution to journal › Journal article › Research › peer-review

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